The vaccine has been available globally since January 2021. Over 350,000 people have already been vaccinated with Ervebo in Guinea, as well as in the 2018-2020 Ebola outbreaks in the DRC. In 2020, the vaccine was officially approved by the FDA and qualified by the WHO for use in people over 18 years, excluding pregnant and breastfeeding women. In 2019, the Ebola vaccine Ervebo was approved for Europe by the European Commission. At the end of 2020, the monoclonal antibodies were officially approved by the US Food and Drug Administration (FDA) for the treatment of Ebola virus disease. Two antibody preparations, Inmazeb and Ebanga, were shown to be highly effective against the Zaire Ebola virus. Virus cultivation is practically impossible in the areas affected by the epidemic, as the necessary safety level cannot be maintained.ĭuring the Ebola outbreak in the DR Congo in 2018 to 2020, various experimental therapeutics were used for the first time and evaluated in a study. Antibody detection is not considered reliable, as not all ill patients develop detectable antibodies and cross-reactions with antigens other than those of the Ebola virus may occur. However, a focus in the diagnosis of Ebola is placed on the RT-PCR test as well as antigen detection. Antigen detection via ELISA (Enzyme Linked Immunosorbent Assay), which is carried out on saliva samples, but more reliably on blood samples.an RT-PCR test, in which a blood sample is taken from the affected person and analysed for viral RNA by real-time polymerase chain reaction (RT-PCR).In order to obtain a definite diagnosis, it is necessary to carry out special diagnostic tests. The symptoms of pregnancy can also resemble Ebola. The Ebola virus disease is often difficult to distinguish from other infectious diseases such as malaria, typhoid, or meningitis simply by looking at the symptoms. Marylyn Addo, a researcher and infectiologist, hypothesised that kidney damage and resulting kidney failure is one of the fatal long-term consequences after contracting Ebola. The cause of death is difficult to determine due to a lack of long-term studies. An international team of researchers led by Mory Keita of the WHO found out in an observational study that Ebola survivors have a 5-fold higher mortality rate up to one year after recovery. Post-Ebola syndrome includes symptoms such as muscle and joint pain, eye diseases and damage to the central nervous system. In individual cases, long-term damage can occur after the disease has been overcome. Many people infected with Ebola die because of organ failure. In the course of the disease, severe symptoms such as organ failure, internal and external bleeding, respiratory distress and delirium can occur. Stomach pain, vomiting and diarrhoea can also occur within the first three to ten days. At first, infected persons suffer from flu-like symptoms such as high fever, physical exhaustion, muscle pain, headache and a sore throat. the time period from infection to the appearance of symptoms, is two to 21 days. ![]() Learn more about the symptoms and treatment of the Ebola virus disease and how we are working to contain the disease. Malteser International was active in the countries that are most at risk of an outbreak of Ebola such as Guinea and Liberia over many years and today supports people in the DR Congo in their fight against the disease with education and prevention measures as well as protective equipment and other supplies. However, the virus remains a constant threat. In May 2021, the Ministry of Health of the DR Congo and WHO announced the outbreak was over. In February 2021, twelve cases of the Ebola virus disease (EVD) were reported in the Congolese province of North Kivu. There were also major outbreaks in the Democratic Republic of the Congo between 20. More than 11,000 died because of the disease. In the largest outbreak to date in West Africa, approximately 28,000 people were infected with the virus between 20. In the past, the mortality rate has fluctuated between 25 and 90 percent, depending on the type of Ebola virus and the medical conditions. According to the World Health Organisation (WHO), an average of 50 percent of people infected with Ebola die. The Ebola virus is one of the most dangerous pathogens in the world. On the run: Health must not be left behind.
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